eBook – “CLINICAL APPLICATIONS
OF PHARMACOGENETICS”

The aim of this (first) chapter is to overview the promises of the pioneering field of
pharmacogenetics towards personalized medicine, completely changing the present
therapeutic paradigm of Done dose fits all patientsE and Dtrial-and-errorE prescriptions to
Dmatching the right dose to the right, specific genetic signature of the patient and at the
right timeE. The review points out the evolution from pharmacogenetics to
pharmacogenomics, as well as the impact of genome-wide-associated studies (GWAS) and
next generation sequencing technologies on deciphering Dmissing heritabilityE and on
validation and approval of pharmacogenetic biomarkers as it is reflected both in regulatory
authorities recommendations and from consortia perspectives.

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